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FBXL19 polyclonal antibody

货号: BS32086

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS32086

Product Name :FBXL19 polyclonal antibody

Swiss-Prot :Q6PCT2

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :F-box/LRR-repeat protein 19: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization . Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner . Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration . Also mediates ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (By similarity). Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides . Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recru...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of FBXL19 protein.

BiowMW :~75.7 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FBL19; F-box/LRR-repeat protein 19; F-box and leucine-rich repeat protein 19

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human FBXL19.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of GAS41 expression in HeLa (A), Raw264.7 (B) whole cell lysates.

免疫沉淀（IP）