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RNF26 polyclonal antibody

货号: BS32060

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS32060

Product Name :RNF26 polyclonal antibody

Swiss-Prot :Q9BY78

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud . Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1 . Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport . Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING . Also required to limit type I interferon response by promoting autophagic degradation of IRF3

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of RNF26 protein.

BiowMW :~47.7 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :RING finger protein 26

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human RNF26.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Ubiquitin expression in HepG2 (A) whole cell lysates.

免疫沉淀（IP）