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ARID5B polyclonal antibody

货号: BS31956

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS31956

Product Name :ARID5B polyclonal antibody

Swiss-Prot :Q14865

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :AT-rich interactive domain-containing protein 5B: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of ARID5B protein.

BiowMW :~132 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DESRT; MRF2; AT-rich interactive domain-containing protein 5B; ARID domain-containing protein 5B; MRF1-like protein; Modulator recognition factor 2; MRF-2

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human ARID5B.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of JAK2 expression in HEK293T (A), SP2/0 (B), H9C2 (C) whole cell lysates.