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USP17L2 polyclonal antibody

货号: BS31916

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31916

Product Name :USP17L2 polyclonal antibody

Swiss-Prot :Q6R6M4

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Ubiquitin carboxyl-terminal hydrolase 17: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of USP17L2 protein.

BiowMW :~59.6 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DUB3; USP17; USP17H; USP17I; USP17J; USP17K; USP17L; USP17M; Ubiquitin carboxyl-terminal hydrolase 17; USP17; Deubiquitinating enzyme 17-like protein 2; Deubiquitinating protein 3; DUB-3; Ubiquitin carboxyl-terminal hydrolase 17-like protein 2; Ubiquitin thioesterase 17-like protein 2; Ubiquitin-specific-processing protease 17-like protein 2

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human USP17L2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of MENTHO expression in Jurkat (A), mouse spleen (B), rat spleen (C) whole cell lysates.