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KLHL25 polyclonal antibody

货号: BS31887

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS31887

Product Name :KLHL25 polyclonal antibody

Swiss-Prot :Q9H0H3

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Kelch-like protein 25: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis . The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low . The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E . The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis . BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTr...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of KLHL25 protein.

BiowMW :~65.9 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ENC2; Kelch-like protein 25; Ectoderm-neural cortex protein 2; ENC-2

Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human KLHL25.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of A-MYB expression in mouse brain (A), rat brain (B) whole cell lysates.

免疫沉淀（IP）