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NR1D2 polyclonal antibody

货号: BS31852

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31852

Product Name :NR1D2 polyclonal antibody

Swiss-Prot :Q14995

Host :Rabbit

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :Nuclear receptor subfamily 1 group D member 2: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded b...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of NR1D2 protein.

BiowMW :~64.6 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Nuclear receptor subfamily 1 group D member 2; Orphan nuclear hormone receptor BD73; Rev-erb alpha-related receptor; RVR; Rev-erb-beta; V-erbA-related protein 1-related; EAR-1R

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human NR1D2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of JAK2 expression in K562 (A), NIH3T3 (B) whole cell lysates.