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DNASE1L3 polyclonal antibody

货号: BS31813

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31813

Product Name :DNASE1L3 polyclonal antibody

Host :Rabbit

Reactivity :Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Deoxyribonuclease gamma: Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends . Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (By similarity). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of DNASE1L3 protein.

BiowMW :~35.7 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DHP2; DNAS1L3; Deoxyribonuclease gamma; DNase gamma; DNase I homolog protein DHP2; Deoxyribonuclease I-like 3; DNase I-like 3; Liver and spleen DNase; LS-DNase; LSD

Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human DNASE1L3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of ATF4 expression in HT22 (A), BV2 (B), C6 (C), PC12 (D), mouse brain (E) whole cell lysates.