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TRIM34 polyclonal antibody

货号: BS31796

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31796

Product Name :TRIM34 polyclonal antibody

Swiss-Prot :Q9BYJ4

Host :Rabbit

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :E3 ubiquitin-protein ligase TRIM34: Functions as antiviral protein and contributes to the defense against retroviral infections . Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses . During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination . In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis . Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis . Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of TRIM34 protein.

BiowMW :~56.9 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :IFP1; RNF21; Tripartite motif-containing protein 34; Interferon-responsive finger protein 1; RING finger protein 21

Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human TRIM34.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Ubiquitin (Linkage specific-K27) expression in Hela (A) whole cell lysates.

免疫沉淀（IP）