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CCDC134 polyclonal antibody

货号: BS31751

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31751

Product Name :CCDC134 polyclonal antibody

Swiss-Prot :Q9H6E4

Host :Rabbit

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :Coiled-coil domain-containing protein 134: Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a microenvironment for HSP90B1 folding . In the CCDC134-containing translocon, STT3A associates with the SRT pseudosubstrate motif of HSP90B1, preventing access to facultative glycosylation sites until folding is completed, preventing hyperglycosylation and subsequent degradation of HSP90B1 . In extracellular secreted form, promotes proliferation and activation of CD8(+) T-cells, suggesting a cytokine-like function . May inhibit ERK and JNK signaling activity . May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling . May also localize in the nucleus: enhances stability of the PCAF histone acetyltransferase (HAT)...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of CCDC134 protein.

BiowMW :~26.6 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Coiled-coil domain-containing protein 134

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human CCDC134.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CD117 expression in BV2 (A) whole cell lysates.

免疫沉淀（IP）