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SGPP1 polyclonal antibody

货号: BS31748

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31748

Product Name :SGPP1 polyclonal antibody

Swiss-Prot :Q9BX95

Host :Rabbit

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :Sphingosine-1-phosphate phosphatase 1: Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid . Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway . Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger . Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resu...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of SGPP1 protein.

BiowMW :~49.1 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Sphingosine-1-phosphate phosphatase 1; SPPase1; Spp1; hSPP1; hSPPase1; Sphingosine-1-phosphatase 1

Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human SGPP1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of UQCRFS1P1 expression in U2OS (A), K562 (B), A431 (C), A549 (D), human skeletal muscle (E), human placenta (F) whole cell lysates.