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PLEKHM1 polyclonal antibody

货号: BS31729

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31729

Product Name :PLEKHM1 polyclonal antibody

Swiss-Prot :Q9Y4G2

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Pleckstrin homology domain-containing family M member 1: Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes . Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion . Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its associa...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of PLEKHM1 protein.

BiowMW :~117 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA0356; Pleckstrin homology domain-containing family M member 1; PH domain-containing family M member 1; 162 kDa adapter protein; AP162

Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human PLEKHM1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of MUC1 expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates.