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LOXL3 polyclonal antibody

货号: BS31704

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31704

Product Name :LOXL3 polyclonal antibody

Swiss-Prot :P58215

Host :Rabbit

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :Lysyl oxidase homolog 3: Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins . Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin . Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity . Oxidation of...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of LOXL3 protein.

BiowMW :~83.2 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :LOXL; Lysyl oxidase homolog 3; Lysyl oxidase-like protein 3

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human LOXL3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of XRCC3 expression in HeLa (A), H1299 (B), U2OS (C), HepG2 (D) whole cell lysates.

Immunohistochemical analysis of XRCC3 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.