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CCDC109B polyclonal antibody

货号: BS31645

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

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No. :BS31645

Product Name :CCDC109B polyclonal antibody

Swiss-Prot :Q9NWR8

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Calcium uniporter regulatory subunit MCUb, mitochondrial: Negative regulator of the mitochondrial calcium uniporter (MCU), a channel that mediates calcium uptake into the mitochondrial matrix . MCUB is required to limit mitochondrial calcium overload during stress . Acts as a dominant-negative regulator that displaces MCU from the functional uniplex complex and thereby decreases the association of calcium sensors MICU1 and MICU2, preventing channel gating . Mitochondrial calcium homeostasis plays key roles in mitochondrial metabolism . Acts as an important regulator of mitochondrial metabolism in response to stress in muscle cells: induced in response to fasting, leading to restrict mitochondrial calcium uptake, resulting in reprogramming of mitochondria toward fatty acid oxidation preference (By similarity). Acts as a regulator of macrophage polarization during skeletal muscle regeneration: inhibition of mitochondrial calcium uptake drives...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of CCDC109B protein.

BiowMW :~39.1 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MCUB; Mitochondrial calcium uniporter regulatory subunit MCUb; MCUb; Coiled-coil domain-containing protein 109B; Essential MCU regulator; EMRE

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human CCDC109B.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of c-SRC (Phospho-Y419) expression in A431 treated with pervanadate (A) whole cell lysates.