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TCRB polyclonal antibody

货号: BS31632

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS31632

Product Name :TCRB polyclonal antibody

Swiss-Prot :P04435

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :T cell receptor beta variable 7-9: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mit...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of TCRB protein.

BiowMW :~13.1 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :T-cell receptor beta chain V region CTL-L17

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human TCRB.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of GPR40 expression in SGC7901 (A), A2780 (B), Panc1 (C), mouse brain (D), rat brain (E) whole cell lysates.

免疫沉淀（IP）