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SmgGDS polyclonal antibody

货号: BS31612

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31612

Product Name :SmgGDS polyclonal antibody

Swiss-Prot :P52306

Host :Rabbit

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :Rap1 GTPase-GDP dissociation stimulator 1: Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP . Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity . Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS . Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions . Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of SmgGDS protein.

BiowMW :~66.3 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Rap1 GTPase-GDP dissociation stimulator 1; Exchange factor smgGDS; SMG GDS protein; SMG P21 stimulatory GDP/GTP exchange protein

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human SmgGDS.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of hnRNP R expression in Hela (A), HepG2 (B) whole cell lysates.

Immunohistochemical analysis of hnRNP R staining in human esophageal cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.