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CLEC12B polyclonal antibody

货号: BS31569

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS31569

Product Name :CLEC12B polyclonal antibody

Swiss-Prot :Q2HXU8

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :C-type lectin domain family 12 member B: Inhibitory receptor postulated to negatively regulate immune and non-immune functions . Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals . Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart . May limit activation of myeloid cell subsets in response to infection or tissue inflammation . May protect target cells against natural killer cell-mediated lysis . May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of CLEC12B protein.

BiowMW :~31.6 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C-type lectin domain family 12 member B; Macrophage antigen H

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human CLEC12B.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of DNAJC6 expression in K562 (A), SHSY5Y (B), U87MG (C), HL60 (D), mouse cerebellum (E), mouse brain (F), rat cerebellum (G) whole cell lysates.