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GFRAL polyclonal antibody

货号: BS31509

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS31509

Product Name :GFRAL polyclonal antibody

Swiss-Prot :Q6UXV0

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :GDNF family receptor alpha-like: Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses . The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future . The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin . Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways . Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (By similarity). The GDF15-GFRAL signal induces expression of genes involved...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of GFRAL protein.

BiowMW :~44.5 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C6orf144; GDNF family receptor alpha-like

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human GFRAL.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of TBX18 expression in U2OS (A), mouse muscle (B), mouse heart (C), rat muscle (D) whole cell lysates.

免疫沉淀（IP）