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WDR41 polyclonal antibody

货号: BS31473

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31473

Product Name :WDR41 polyclonal antibody

Swiss-Prot :Q9HAD4

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/100)

Background :WD repeat-containing protein 41: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy . The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation . As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function . The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of WDR41 protein.

BiowMW :~51.7 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :WD repeat-containing protein 41

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human WDR41.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CD11b expression in mouse lung (A) whole cell lysates.

Immunohistochemical analysis of CD11b staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.