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ORMDL2 polyclonal antibody

货号: BS31460

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS31460

Product Name :ORMDL2 polyclonal antibody

Swiss-Prot :Q53FV1

Host :Rabbit

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :ORM1-like protein 2: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels . When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity)

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of ORMDL2 protein.

BiowMW :~17.4 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ORM1-like protein 2; Adoplin-2

Immunogen :A synthetic peptide encompassing a sequence within the Central region of human ORMDL2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of EED expression in MCF7 (A), A549 (B), mouse lung (C) whole cell lysates.

免疫沉淀（IP）