Product Name :UBE2W polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/2000)
Background :Ubiquitin-conjugating enzyme E2 W: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini . Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway . In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ub...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of UBE2W protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :UBC16; Ubiquitin-conjugating enzyme E2 W; N-terminus-conjugating E2; Ubiquitin carrier protein W; Ubiquitin-conjugating enzyme 16; UBC-16; Ubiquitin-protein ligase W
Immunogen :Recombinant fusion protein of human UBE2W.
Modification :Unmodification
