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Selenoprotein N polyclonal antibody

货号: BS31318

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS31318

Product Name :Selenoprotein N polyclonal antibody

Swiss-Prot :Q9NZV5

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/2000)

Background :Selenoprotein N: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity . Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Selenoprotein N protein

BiowMW :~65.8 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SELN; Selenoprotein N; SelN

Immunogen :Recombinant fusion protein of human Selenoprotein N.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of ATP1A3 expression in NCIH292 (A) whole cell lysates.

免疫沉淀（IP）