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Makorin-3 polyclonal antibody

货号: BS31264

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS31264

Product Name :Makorin-3 polyclonal antibody

Swiss-Prot :Q13064

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/2000)

Background :E3 ubiquitin-protein ligase makorin-3: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Acts as a key developmental timer that helps ensure puberty begins at the appropriate age, by inhibiting premature activation of the reproductive hormone cascade. Epigenetically regulates GNRH1 transcription by disrupting the binding of methyl-DNA binding protein 3/MBD3 to the promoter of GNRH1. Mechanistically, mediates the non-proteolytic ubiquitination of MBD3 at multiple sites with 'Lys27' ubiquitin linkages and thereby regulates the methylation status of the genome, including GNRH1 promoter . Modulates the stability and translation of GNRH1 mRNA by mediating the non-proteolytic ubiquitination of PABP family members PABPC1, PABPC3 and PABPC4 at multiple sites . Also participates in the maintenance of genomic and epigenomic stability by regulating the abundance of APEX2 via 'Lys-48...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Makorin-3 protein

BiowMW :~55.6 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :D15S9; RNF63; ZNF127; Probable E3 ubiquitin-protein ligase makorin-3; RING finger protein 63; Zinc finger protein 127

Immunogen :Recombinant fusion protein of human Makorin-3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CACNG3 expression in human brain (A), mouse brain (B), rat brain (C) whole cell lysates.

免疫沉淀（IP）