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METTL1 polyclonal antibody

货号: BS31260

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31260

Product Name :METTL1 polyclonal antibody

Swiss-Prot :Q9UBP6

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/2000)

Background :tRNA (guanine-N(7)-)-methyltransferase: Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) . Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop . M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay . Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs . Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation . Also methylates a specific subset of miRNAs, such as let-7 . N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of METTL1 protein

BiowMW :~31.5 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C12orf1; tRNA (guanine-N(7)-)-methyltransferase (Methyltransferase-like protein 1; tRNA (guanine(46)-N(7))-methyltransferase; tRNA(m7G46)-methyltransferase

Immunogen :Recombinant fusion protein of human METTL1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of HSD17B1 expression in U87MG (A), rat ovary (B) whole cell lysates.