Product Name :ITM2C polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/2000)
Background :Integral membrane protein 2C: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity)
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ITM2C protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :BRI3; Integral membrane protein 2C; Cerebral protein 14; Transmembrane protein BRI3
Immunogen :Recombinant fusion protein of human ITM2C.
Modification :Unmodification
