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ICAP1 polyclonal antibody

货号: BS31239

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS31239

Product Name :ICAP1 polyclonal antibody

Swiss-Prot :O14713

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/2000)

Background :Integrin beta-1-binding protein 1: Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of ICAP1 protein

BiowMW :~21.8 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ICAP1; Integrin beta-1-binding protein 1; Integrin cytoplasmic domain-associated protein 1; ICAP-1

Immunogen :Recombinant fusion protein of human ICAP1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Frizzled 9 expression in HEK293T (A), mouse heart (B), rat muscle (C) whole cell lysates.

免疫沉淀（IP）