产品类别

联系我们

电话:18013895086

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

HERC5 polyclonal antibody

货号: BS31226

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS31226

Product Name :HERC5 polyclonal antibody

Swiss-Prot :Q9UII4

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/500 - 1/2000)

Background :E3 ISG15--protein ligase HERC5: Major E3 ligase for ISG15 conjugation . Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Mediates ISGylation of the phosphatase PTEN leading to its degradation, thus alleviating its suppression of the PI3K-AKT signaling pathway and promoting the production of cytokines that facilitate bacterial clearance . Interferes with the function of key viral structural proteins such as ebolavirus structural protein VP40 or HIV-1 protein GAG . Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to for...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of HERC5 protein

BiowMW :~117 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CEB1; CEBP1; E3 ISG15--protein ligase HERC5; Cyclin-E-binding protein 1; HECT domain and RCC1-like domain-containing protein 5

Immunogen :Recombinant fusion protein of human HERC5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of p47 phox expression in HEK293T (A), Hela (B), mouse lung (C), mouse liver (D), rat lung (E), rat liver (F), rat spleen (G) whole cell lysates.