Product Name :FBL2 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/2000)
Background :F-box/LRR-repeat protein 2: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin . This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin . Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) . SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy . PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for forma...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of FBL2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :FBL2; FBL3; F-box/LRR-repeat protein 2; F-box and leucine-rich repeat protein 2; F-box protein FBL2/FBL3
Immunogen :Recombinant fusion protein of human FBL2.
Modification :Unmodification
