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Cytochrome P450 7A1 polyclonal antibody

货号: BS31186

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS31186

Product Name :Cytochrome P450 7A1 polyclonal antibody

Swiss-Prot :P22680

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/2000)

Background :Cytochrome P450 7A1: A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis . 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol . Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Cytochrome P450 7A1 protein

BiowMW :~57.7 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CYP7; Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1

Immunogen :Recombinant fusion protein of human Cytochrome P450 7A1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of OGT expression in THP1 (A), Jurkat (B) whole cell lysates.

免疫沉淀（IP）