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BBS5 polyclonal antibody

货号: BS31161

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS31161

Product Name :BBS5 polyclonal antibody

Swiss-Prot :Q8N3I7

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/2000)

Background :BBSome complex member BBS5: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex cili...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of BBS5 protein

BiowMW :~38.8 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Bardet-Biedl syndrome 5 protein

Immunogen :Recombinant fusion protein of human BBS5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of MT-ND1 expression in HeLa (A) whole cell lysates.

免疫沉淀（IP）