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TAP1 polyclonal antibody

货号: BS31142

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31142

Product Name :TAP1 polyclonal antibody

Swiss-Prot :Q03518

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/2000)

Background :Antigen peptide transporter 1: ABC transporter associated with antigen processing. In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules . Uses the chemical energy of ATP to export peptides against the concentration gradient . During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle . Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of TAP1 protein.

BiowMW :~81.0 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ABCB2; PSF1; RING4; Y3; Antigen peptide transporter 1; APT1; ATP-binding cassette sub-family B member 2; Peptide supply factor 1; Peptide transporter PSF1; PSF-1; Peptide transporter TAP1; Peptide transporter involved in antigen processing 1; Really interesting new gene 4 protein

Immunogen :Recombinant fusion protein of human TAP1

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of VEGFD expression in rat lung (A) whole cell lysates.