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Calcium Sensing Receptor polyclonal antibody

货号: BS31101

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS31101

Product Name :Calcium Sensing Receptor polyclonal antibody

Host :Rabbit

Reactivity :Mouse, Rat

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/100 - 1/200)

Background :Extracellular calcium-sensing receptor: G protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis . Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands . In kidneys, acts as a key regulator of renal tubular calcium resorption . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). CASR is coupled with different G(q)/G(11), G(i)/G(o)- or G(s)-classes of G proteins depending on the context . In the parathyroid and kidney, CASR signals through G(q)/G(11) and G(i)/G(o) G proteins: G(q)/G(11) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inosi...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Calcium Sensing Receptor protein.

BiowMW :~121 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :GPRC2A; PCAR1; Extracellular calcium-sensing receptor; CaSR; Parathyroid cell calcium-sensing receptor 1; PCaR1

Immunogen :A synthetic peptide encompassing a sequence of mouse Calcium Sensing Receptor.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CD35 expression in A549 (A), NIH3T3 (B), mouse liver (C), mouse brain (D) whole cell lysates.

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