产品类别

联系我们

电话:18013895086

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Beta-catenin polyclonal antibody

货号: BS31096

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS31096

Product Name :Beta-catenin polyclonal antibody

Host :Rabbit

Reactivity :Mouse, Rat

Applications :WB, IHC

Application_all :WB (1/2000 - 1/5000), IHC (1/200 - 1/500)

Background :Catenin beta-1: Key downstream component of the canonical Wnt signaling pathway . In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Also acts as a coactivator for other transcription factors, such as NR5A2 (By similarity). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex . Acts as a ne...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Beta-catenin protein.

BiowMW :~85.5 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CTNNB; Catenin beta-1; Beta-catenin

Immunogen :Recombinant protein corresponding to mouse Beta-catenin.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of XBP1 expression in HT29 (A), Jurkat (B) whole cell lysates.

免疫沉淀（IP）