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Bestrophin-2 polyclonal antibody

货号: BS31095

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31095

Product Name :Bestrophin-2 polyclonal antibody

Host :Rabbit

Reactivity :Mouse, Rat

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/100 - 1/200)

Background :Bestrophin-2: Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) . Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide . Calcium-binding triggers the dilation of the aperture, but calcium-dependent gating is only effective when the size of the passing anion is bigger than the closed aperture (By similarity). Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion . In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate; binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans (By similarity). Also exhibits a directional pe...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Bestrophin-2 protein.

BiowMW :~57.0 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :VMD2L1; Bestrophin-2; Vitelliform macular dystrophy 2-like protein 1

Immunogen :A synthetic peptide encompassing a sequence of mouse Bestrophin-2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of PFKL expression in SGC7901 (A), HepG2 (B), HEK293T (C), AML12 (D) whole cell lysates.

Immunohistochemical analysis of PFKL staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.