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RagC polyclonal antibody

货号: BS31077

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS31077

Product Name :RagC polyclonal antibody

Swiss-Prot :Q9HB90

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Ras-related GTP-binding protein C: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade . Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) . In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB . This is a crucial step in the activation of the MTOR signaling cascade by amino acids . Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of RagC protein.

BiowMW :~44.2 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Ras-related GTP-binding protein C; Rag C; RagC; GTPase-interacting protein 2; TIB929

Immunogen :A synthetic peptide encompassing a sequence within the C-term region of human RagC.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of NAT-2 expression in HEK293T (A), mouse kidney (B) whole cell lysates.

免疫沉淀（IP）