Product Name :BCAR3 polyclonal antibody
Applications :WB, IHC, IF/ICC
Application_all :WB (1/500 - 1/1000), IHC (1/100 - 1/200), IF/ICC (1/100 - 1/500)
Background :Breast cancer anti-estrogen resistance protein 3: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers . Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis . Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 . Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis . Required for the maintenance of ocular lens morphology and structural integrity, potentially via reg...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of BCAR3 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :NSP2; SH2D3B; Breast cancer anti-estrogen resistance protein 3; Novel SH2-containing protein 2; SH2 domain-containing protein 3B
Immunogen :A synthetic peptide encompassing a sequence within the C-term region of human BCAR3.
Modification :Unmodification
