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VRK3 polyclonal antibody

货号: BS31012

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS31012

Product Name :VRK3 polyclonal antibody

Swiss-Prot :Q8IV63

Host :Rabbit

Reactivity :Human, Rat

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/100)

Background :Serine/threonine-protein kinase VRK3: Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis . Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death . For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of VRK3 protein.

BiowMW :~52.9 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Inactive serine/threonine-protein kinase VRK3; Serine/threonine-protein pseudokinase VRK3; Vaccinia-related kinase 3

Immunogen :A synthetic peptide encompassing a sequence within the center region of human VRK3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of HLA-DQA1 expression in mouse kidney (A), rat kidney (B) whole cell lysates.

免疫沉淀（IP）