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GPR37L1 polyclonal antibody

货号: BS30991

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS30991

Product Name :GPR37L1 polyclonal antibody

Swiss-Prot :O60883

Host :Rabbit

Reactivity :Human

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/200)

Background :G protein-coupled receptor . Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade . However, other studies have shown that prosaposin does not increase activity . It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha . Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity)

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of GPR37L1 protein.

BiowMW :~52.8 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ETBRLP2; Prosaposin receptor GPR37L1; Endothelin B receptor-like protein 2; ETBR-LP-2; G-protein coupled receptor 37-like 1

Immunogen :A synthetic peptide encompassing a sequence within the N-term region of human GPR37L1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of NDUFA4 expression in H446 (A), mouse kidney (B), mouse liver (C), rat kidney (D) whole cell lysates.

Immunohistochemical analysis of NDUFA4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.