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PWWP2B polyclonal antibody

货号: BS30990

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS30990

Product Name :PWWP2B polyclonal antibody

Swiss-Prot :Q6NUJ5

Host :Rabbit

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/100 - 1/200)

Background :PWWP domain-containing protein 2B: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes . Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z . Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity)

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of PWWP2B protein.

BiowMW :~64.0 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PWWP2; PWWP domain-containing protein 2B

Immunogen :A synthetic peptide encompassing a sequence within the center region of human PWWP2B.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of MOCS3 expression in HepG2 (A), Jurkat (B), mouse liver (C), rat heart (D) whole cell lysates.

Immunohistochemical analysis of MOCS3 staining in mouse kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.