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Dematin polyclonal antibody

货号: BS30973

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS30973

Product Name :Dematin polyclonal antibody

Swiss-Prot :Q08495

Host :Rabbit

Reactivity :Human, Mouse, Bovine

Applications :WB, IHC, IF/ICC

Application_all :WB (1/500 - 1/1000), IHC (1/100 - 1/200), IF/ICC (1/100 - 1/500)

Background :Dematin: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Dematin protein.

BiowMW :~45.5 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DMT; EPB49; Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9

Immunogen :A synthetic peptide encompassing a sequence within the C-term region of human Dematin.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of MED14 expression in Jurkat (A), mouse brain (B) whole cell lysates.

免疫沉淀（IP）