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IFIT5 polyclonal antibody

货号: BS30963

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS30963

Product Name :IFIT5 polyclonal antibody

Swiss-Prot :Q13325

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Interferon-induced protein with tetratricopeptide repeats 5: Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments . Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner . Also recognizes and selectively binds AT-rich dsDNA . Additionally, as a mediator in innate immunity, positively regulates IKK-NFKB signaling by sinergizing the recrui...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of IFIT5 protein.

BiowMW :~55.8 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ISG58; RI58; Interferon-induced protein with tetratricopeptide repeats 5; IFIT-5; Interferon-induced 58 kDa protein; Retinoic acid- and interferon-inducible 58 kDa protein; P58

Immunogen :A synthetic peptide encompassing a sequence within the center region of human IFIT5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Neuropilin 2 expression in 293T (A), NIH3T3 (B), PC12 (C) whole cell lysates.