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GPR97 polyclonal antibody

货号: BS30946

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS30946

Product Name :GPR97 polyclonal antibody

Swiss-Prot :Q86Y34

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/100 - 1/500)

Background :Adhesion G protein-coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase . ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity . May also signal through G-alpha(q)-proteins; additional evidence are however required to confirm this result in vivo . Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity . Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 . Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and m...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of GPR97 protein.

BiowMW :~60.9 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PGR26; Probable G-protein coupled receptor 97; G-protein coupled receptor PGR26

Immunogen :A synthetic peptide encompassing a sequence within the center region of human GPR97.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CD25 expression in Hela (A), MOLT4 (B), HEK293 (C), A549 (D), Jurkat (E), K562 (F), COS7 (G), PC12 (H), NIH/3T3 (I) whole cell lysates.

Immunohistochemical analysis of CD25 staining in human rectum cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.