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MARCH5 polyclonal antibody

货号: BS30932

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS30932

Product Name :MARCH5 polyclonal antibody

Swiss-Prot :Q9NX47

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/100 - 1/500)

Background :E3 ubiquitin-protein ligase MARCHF5: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission and as an important regulator of immune response . Plays a crucial role in maintaining mitochondrial homeostasis by regulating the dynamics of mitochondria through the ubiquitination of key proteins involved in fission and fusion such as FIS1, DNM1L and MFN1 . Acts as a critical determinant of mitotic apoptosis through both MCL1-dependent and -independent pathways (By similarity). Turns off persistent immune signaling by degrading oligomeric complexes of retinoic acid-inducible gene I/DDX58 and mitochondrial antiviral-signaling protein/MAVS formed upon RNA virus infection . Promotes STING-mediated type-I interferon production via 'Lys-63'-linked ubiquitination of STING1 thereby preserving its activity and preventing t...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of MARCH5 protein.

BiowMW :~31.2 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :RNF153; E3 ubiquitin-protein ligase MARCH5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; MARCH-V; Mitochondrial ubiquitin ligase; MITOL; RING finger protein 153

Immunogen :A synthetic peptide encompassing a sequence within the center region of human MARCH5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Ku70 expression in HEK293T (A), Hela (B), A2780 (C), H460 (D) whole cell lysates.

Immunohistochemical analysis of Ku70 staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.