Product Name :CDCA7 polyclonal antibody
Application_all :WB (1/500 - 1/1000), IF/ICC (1/100 - 1/500)
Background :Cell division cycle-associated protein 7: Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis . Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognizes hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns . May play a role as transcriptional regulator
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CDCA7 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :JPO1; Cell division cycle-associated protein 7; Protein JPO1
Immunogen :A synthetic peptide encompassing a sequence within the center region of human CDCA7.
Modification :Unmodification
