产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Bcl-2 Polyclonal Antibody

货号: BS65626

价格：￥ 1140

货期：现货（1-2个工作日）

25ug 50ug 100ug 200ug

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65626

Product Name :Bcl-2 Polyclonal Antibody

Swiss-Prot :P49950

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF/ICC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF/ICC: 1:50~1:200

Background :The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Bcl-2 Polyclonal Antibody detects endogenous levels of Bcl-2 protein.

BiowMW :28 kD

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Apoptosis regulator Bcl-2

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BCL-2.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of BCL-2 expression in SHSY5Y (A), MCF7 (B), Hela (C), mouse kidney (D), mouse muscle (E), rat kidney (F), rat muscle (G) whole cell lysates.

Immunohistochemical analysis of BCL-2 staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of BCL-2 staining in HepG2 cells.

Effects of Tetramethylpyrazine on Neuronal Apoptosis in the Superficial Dorsal Horn in a Rat Model of Neuropathic Pain

JournalAmerican Journal Of Chinese Medicine

ApplicationIHC

IF3.682

SpeciesRat

PMID23227794
Neutrophil Gelatinase-Associated Lipocalin Protects Renal Tubular Epithelial Cell in Ischemic/Reperfusion Injury Rats via Apoptosis-Regulating Proteins

JournalRenal Failure

ApplicationIHC

IF1.985

SpeciesRat

PMID
Human mammary microenvironment better regulates the biology of human breast cancer in humanized mouse model

JournalMedical Oncology

ApplicationWB

IF2.834

SpeciesMouse

PMID
Downregulation of angiogenin inhibits the growth and induces apoptosis in human bladder cancer cells through regulating AKT/mTOR signaling pathway

JournalJournal Of Molecular Histology

ApplicationWB,IHC

IF2.611

SpeciesHuman,Mouse

PMID25564356
Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model

JournalNeuropeptides

ApplicationIHC,WB

IF2.407

SpeciesMouse

PMID30017231