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Bcl-2 Polyclonal Antibody

货号: BS65626

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS65626

Product Name :Bcl-2 Polyclonal Antibody

Swiss-Prot :P49950

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF/ICC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF/ICC: 1:50~1:200

Background :The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Bcl-2 Polyclonal Antibody detects endogenous levels of Bcl-2 protein.

BiowMW :28 kD

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Apoptosis regulator Bcl-2

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BCL-2.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of BCL-2 expression in SHSY5Y (A), MCF7 (B), Hela (C), mouse kidney (D), mouse muscle (E), rat kidney (F), rat muscle (G) whole cell lysates.

Immunohistochemical analysis of BCL-2 staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of BCL-2 staining in HepG2 cells.

(+)-Borneol exerts neuroprotective effects via suppressing the NF-κB pathway in the pilocarpine-induced epileptogenesis rat model

JournalBRAIN RESEARCH

ApplicationWB

IF3.61

SpeciesRat

PMID37127175
Preservation solution protects isolated hair micrografts by inhibiting apoptosis of hair bulb

Journal10.1016/j.lfs.2024.123292

ApplicationWB

IF5.2

SpeciesHuman

PMID39643038