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HSP60 (6C8) monoclonal antibody

货号: MB0177

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0177

Product Name :HSP60 (6C8) monoclonal antibody

Swiss-Prot :P10809

Host :Mouse

Reactivity :Human,Mouse,Rat

Applications :WB IF IP

Application_all :WB: 1:1000 IP: 1:50~200 IF: 1:50~200

Background :HSPs (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the low molecular weight HSPs, the immunophilins, and the HSP 110 family. The constitutively expressed mitochondrial protein HSP 60 shares the ability to recognize and stabilize proteins during folding, assembly and disassembly with other HSP family members. The mitochondrial and cytosolic localization of HSP 60, combined with its binding and catalysis of folding of newly synthesized proteins destined for the mitochondrial matrix, classify this protein as a molecular chaperone. An additional role of HSP 60 is to act as a cell surface marker forr γ/δ T cell recognition.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of HSP60 and does not cross-react with related proteins.

BiowMW :Predicted band size:60KDa Observed band size:60KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Mitochondrial Control of Apoptosis,

Alternative Name :60 kDa heat shock protein, mitochondrial; 60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; HSP-60; Hsp60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; HSPD1; HSP60

Immunogen :Purified recombinant human Hsp60 protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Hsp60 in Hela,Raji,Jurkat,C6,C2C12 and 3T3 cell lysates using Hsp60 mouse mAb (1:1000 diluted).

Immunocytochemistry staining of HeLa cells fixed with -20℃ Methanol and using Hsp60 mouse mAb (dilution 1:100).

Immunoprecipitation analysis of Hela cell lysates using Hsp60 mouse mAb.

Telekin induces apoptosis associated with the mitochondria-mediated pathway in human hepatocellular carcinoma cells

JournalBiological & Pharmaceutical Bulletin

ApplicationWB

IF1.863

SpeciesHuman

PMID23657090