产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

BCL2 polyclonal antibody

货号: CAS7511

价格：￥ ——

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :CAS7511

Product Name :BCL2 polyclonal antibody

Swiss-Prot :P10415

Host :Rabbit

Reactivity :Human,Rat

Applications :WB

Application_all :WB: 1:2000~1:5000

Background :Bcl-2 exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release. It has been implicated in modulating mitochondrial calcium homeostasis and proton flux . Several phosphorylation sites have been identified within Bcl-2 including Thr56, Ser70, Thr74, and Ser87. It has been suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events. Mutation of Bcl-2 at Thr56 or Ser87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes. Interleukin-3 and JNK-induced Bcl-2 phosphorylation at Ser70 may be required for its enhanced anti-apoptotic functions.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :BCL2 polyclonal antibody detects endogenous levels of BCL2 protein.

BiowMW :~ 30 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis,Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,Death Receptor Signaling,

Alternative Name :Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; MYC

Immunogen :Recombinant protein of human BCL2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of BCL2 pAb at 1:2000 dilution Lane1:THP-1 whole cell lysate(20ug) Lane2:The Thymus tissue lysate of Rat(60ug) Lane3:HUT78 whole cell lysate(60ug) Lane4:A2780 whole cell lysate(60ug) Lane5: HEK293T whole cell lysate(60ug)

Metabolomics and transcriptomics indicated the molecular targets of copper to the pig kidney

JournalEcotoxicology And Environmental Safety

ApplicationWB

IF6.291

SpeciesPig

PMID33945902
Novel dihydroartemisinin derivative Mito-DHA5 induces apoptosis associated with mitochondrial pathway in bladder cancer cells

JournalBMC Pharmacology & Toxicology

ApplicationWB

IF2.483

SpeciesHuman

PMID35057867
Expression of STING Is Increased in Monocyte-derived Macrophages and Contributes to Liver Inflammation in Hepatic Ischemia-Reperfusion Injury

JournalAMERICAN JOURNAL OF PATHOLOGY

ApplicationWB

IF5.77

SpeciesMouse

PMID36174680
Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction

JournalOxidative Medicine and Cellular Longevity

ApplicationWB

IF7.31

SpeciesHuman

PMID36567856
Inhibition of FEN1 promotes DNA damage and enhances chemotherapeutic response in prostate cancer cells

JournalMEDICAL ONCOLOGY

ApplicationWB

IF3.4

SpeciesHuman

PMID37452976