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ACAN polyclonal antibody

货号: BS60808

价格：￥ ——

货期：现货（1-2个工作日）

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No. :BS60808

Product Name :ACAN polyclonal antibody

Swiss-Prot :P16112

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage. Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican. Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification. Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ACAN polyclonal antibody detects endogenous levels of ACAN protein.

BiowMW :~ 260 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1; ACAN; AGC1; CSPG1; MSK16

Immunogen :Synthetic peptide, corresponding to Human ACAN.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ACAN polyclonal antibody at 1:500 dilution Lane1:CT26 whole cell lysate Lane2:C6 whole cell lysate Lane3:Hela whole cell lysate

Osteoclast-derived exosomal miR-212-3p suppressed the anabolism and accelerated the catabolism of chondrocytes in osteoarthritis by targeting TGF-β1/Smad2 signaling

JournalARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ApplicationWB,IF

IF3.9

SpeciesMouse

PMID38000494