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ADAM19 polyclonal antibody

货号: BS60747

价格：￥ ——

货期：现货（1-2个工作日）

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No. :BS60747

Product Name :ADAM19 polyclonal antibody

Swiss-Prot :Q9H013

Host :Rabbit

Reactivity :Human

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The ADAM (a disintegrin and metalloprotease) protein family, which includes over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases, plays a role in cell-cell and cell-matrix interface related processes, including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. The ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in a wide range of mammalian tissues and several are abundantly expressed in the male reproductive tract . Expression of ADAM19, also designated meltrin b, is highest in the peripheral nervous system during embryogenesis, but is also apparent in placenta, brain, heart, lung, leukocytes, and SW480 cells . ADAM19 also serves as a dendritic cell marker. Truncation of ADAM19 in its cysteine-rich domain is necessary to exert its proteolytic activity on specific substrates, including a2-macroglobulin .

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ADAM19 polyclonal antibody detects endogenous levels of ADAM19 protein.

BiowMW :~ 105 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Disintegrin and metalloproteinase domain-containing protein 19; ADAM 19; Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MADDAM; ADAM19; MLTNB; FKSG34

Immunogen :A synthetic peptide corresponding to residues in Human ADAM19

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ADAM19 polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate

Immunohistochemistry (IHC) analyzes of ADAM19 pAb in paraffin-embedded human breast carcinoma tissue at 1:50,showing cytoplasmic and membrane staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.