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AChRα7 polyclonal antibody（KU）

货号: BS60391

价格：￥ 660

货期：现货（1-2个工作日）

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No. :BS60391

Product Name :AChRα7 polyclonal antibody（KU）

Swiss-Prot :P36544/Q494W8

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:5000~1:1000 0

Background :Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChRα7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 that is associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, a protein superfamily that mediates signal transmission at synapses. CHRFAM7A is expressed in the hippocampus. Alternative splicing of the CHRFAM7A gene produces two splice variants.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AChRα7 polyclonal antibody detects endogenous levels of AChRα7 protein.

BiowMW :~ 56 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Neuronal acetylcholine receptor subunit alpha-7; CHRNA7; NACHRA7; CHRNA7-FAM7A fusion protein; CHRNA7-DR1; D-10; CHRFAM7A

Immunogen :recombinant protein

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of AChRα7 pAb at 1:5000 dilution Lane1:PC12 whole cell lysate(40ug) Lane2:AML-12 whole cell lysate(40ug) Lane3:HCT116 whole cell lysate(40ug) Lane4:EC9706 whole cell lysate(40ug) Lane5:SGC7901 whole cell lysate(40ug) Lane6:A549 whole cell lysate(40ug) Lane7:HEK293T whole cell lysate(40ug) Lane8:HepG2 whole cell lysate(40ug)

S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3β signal pathway in rats

JournalNeurochemistry International

ApplicationWB

IF3.994

SpeciesRat

PMID29355569
Cholinergic drugs reduce metabolic inflammation and diabetic myocardial injury by regulating the gut bacterial component lipopolysaccharide-induced ERK/Egr-1 pathway

JournalFASEB JOURNAL

ApplicationWB

IF5.834

SpeciesMouse,Rat

PMID37039813